Angioedema is also a place of swelling of the lower layer of the skin and tissue just underneath the skin or mucous membranes. The swelling can happen in the face, tongue, larynx, stomach, or legs and arms. Often it's connected with Infection, which can be swelling within the top skin. Onset is generally over minutes to hours.



The underlying mechanism typically involves histamine or bradykinin. The version associated with histamine would be to thanks an allergic reaction to brokers like insect bites, foods, or drugs. The version associated with bradykinin may happen because of an inherited issue called C1 esterase inhibitor deficiency, drugs called angiotensin converting enzyme inhibitors, or even a lymphoproliferative disease.

Hives — also known as urticaria (ur-tih-KAR-e-uh) — is a skin reaction that causes itchy welts, which can range in size from small spots to large blotches several inches in diameter. Hives can be triggered by exposure to certain foods, medications or other substances.

Angioedema is a related type of swelling that affects deeper layers in your skin, often around your face and lips. In most cases, hives and angioedema are harmless and don't leave any lasting marks, even without treatment.

The most common treatment for hives and angioedema is antihistamine medication. Serious angioedema can be life-threatening if swelling causes your throat or tongue to block your airway.

Signs and symptoms of angioedema causes

The skin of the face, typically round the moutharea, and the mucosa of the mouth or throat, in addition to the tongue, swell within the span of seconds to hours. The swelling may also occur elsewhere, commonly from the palms. The swelling may be itchy or debilitating. There can also be marginally decreased feeling in the affected regions because of compression of the nerves. Urticaria (Infection) can grow concurrently.

In severe cases, stridor of the airway occurs, with gasping or wheezy inspiratory breath sounds and decreasing oxygen levels. Tracheal intubation is expected in such situations to stop respiratory arrest and threat of death.

At times, the cause is recent vulnerability to a allergen (e.g. peanuts), but more frequently it's either idiopathic(unknown) or only weakly associated with allergen exposure.

In hereditary angioedema, often no direct cause is identifiable, although mild, including dental work and other stimuli, can cause attacks. There is usually no associated itch or urticaria, as it is not an allergic response. Patients with HAE can also have recurrent episodes (often called "attacks") of abdominal pain, usually accompanied by intense vomiting, weakness, and in some cases, watery diarrhea, and an unraised, nonitchy splotchy/swirly rash. These stomach attacks can last one to five days on average, and can require hospitalization for aggressive pain management and hydration.



Source: https://aderonkebamidele.com/angioedema-causes-symptoms-prevention/